| Fri. 09/03/10 | Phantom Buffalo / Run-On Sentence / the Hairdresser's Husband | Mayo Street Arts | 8:30pm | |  |
| Fri. 09/03/10 | Isa Christ / Kyle Clyde / Hott Tubb / Endless Caverns | Strange Maine | 8:00pm | | |
| Fri. 09/03/10 | Dooryard Presents: Robber & Thief / Glitterazzi / DJ Polygone | Slainte | 8:00pm | | |
| Sat. 09/04/10 | Joshua Radin | LL Bean Discovery Park | 7:30pm | | |
| Sun. 09/05/10 | Big Blood / Human Adult Band | Apohadion | 8:30pm | | |
| Wed. 09/08/10 | Ozomatli | Port City Music Hall | 8:00pm |  | |
| Sat. 09/11/10 | SPACE Gallery BLOCK PARTY w/ Garotas Suecas | SPACE Gallery | 6:00pm | | |
| Sat. 09/11/10 | Block Party Afterweirdness: Rattlesnakes / Antiseptic / Have Fun | Apohadion | 9:00pm | | |
| Sun. 09/12/10 | Crank Sturgeon / Sterile Garden | Strange Maine | 8:00pm | | |
| Wed. 09/15/10 | Swingin' Utters / The Copyrights / Covered In Bees | Geno's | 9:00pm | | |
| Wed. 09/15/10 | Woods / MV&EE / Herbcraft | SPACE Gallery | 8:00pm | | |
| Thu. 09/16/10 | Donna The Buffalo / Caravan of Thieves | Empire Dine & Dance | 9:00pm | | |
| Fri. 09/17/10 | South China / Selbyville / Jakob Battick & Friends | Mayo Street Arts | 8:30pm | | |
| Fri. 09/17/10 | Dan-a-palooza (Dan Knudsen) | Strange Maine | 8:00pm | | |
| Sun. 09/19/10 | The Wailers | Port City Music Hall | 7:00pm | | |
| Tue. 09/21/10 | Mastodon | Port City Music Hall | 7:30pm | | |
| Fri. 09/24/10 | Yo Gabba Gabba! Live w/Biz Markie | Merrill Auditorium | 11:00am | | |
| | | 5:00pm | | |
| Fri. 09/24/10 | Sheryl Crow / Brandi Carlile | Cumberland County Civic Center | 8:00pm | | |
| Sat. 09/25/10 | Covered In Bees (cd release party) | Geno's | 9:00pm | | |
| Sat. 09/25/10 | Ember Shrag / Arborea / Jeff Platz String Trio with percussion | Mayo Street Arts | 9:00pm | | |
| Thu. 09/30/10 | Murder By Death / Samantha Crain / Ninja Gun | SPACE Gallery | 8:00pm | | |
| Fri. 10/01/10 | Glenn Jones / Meg Baird / Micah Blue Smaldone / Arborea | Mayo Street Arts | 8:00pm | | |
| Fri. 10/01/10 | Marnie Stern / Dead Man's Clothes | Venue Music Bar [Portland] | 8:00pm | | |
| Sat. 10/02/10 | Paper Castles | Mayo Street Arts | 8:00pm | | |
| Sun. 10/03/10 | Round Mountain | Mayo Street Arts | 8:00pm | | |
| Mon. 10/11/10 | Deerhoof / Xiu Xiu / Father Murphy | SPACE Gallery | 8:00pm | | |
| Tue. 10/12/10 | Casiotone For The Painfully Alone / Otouto / Hello Shark | The Oak & The Ax | TBD | | |
| Thu. 10/14/10 | Jill Sobule | One Longfellow Square | 8:00pm | | |
| Thu. 10/14/10 | Fountains Of Wayne | Port City Music Hall | 8:00pm | | |
| Fri. 10/15/10 | My Morning Jacket | The State Theatre | 7:30pm | | |
| Sat. 10/16/10 | Black Swans | Mayo Street Arts | 8:00pm | | |
| Sun. 10/17/10 | State Theatre Open House/PMF Launch: Darien Brahms / Jacob & The House Of Fire / Brenda / Sidecar Radio / Atomik | The State Theatre | 1:00pm | | |
| Sun. 10/17/10 | The Black Swans / Milagres / Drab Pony | The Oak & The Ax | 8:00pm | | |
| Tue. 10/19/10 | The Hold Steady | Port City Music Hall | 8:00pm | | |
| Tue. 10/19/10 | Red Medicine / Huak | Slainte | 9:00pm | | |
| Wed. 10/20/10 | OK Go | Port City Music Hall | 8:00pm | | |
| Thu. 10/21/10 | High On Fire / Torche / Kylesa | Port City Music Hall | 8:00pm | | |
| Fri. 10/22/10 | Josh Ritter & The Royal City Band / The Low Anthem | The State Theatre | 8:00pm | | |
| Sat. 10/23/10 | Matt Weston / id m theft able | Strange Maine | 8:00pm | | |
| Mon. 10/25/10 | Margaret Cho | The State Theatre | 7:30pm | | |
| Tue. 10/26/10 | Goo Goo Dolls / The Spill Canvas | The State Theatre | 7:30pm | | |
| Wed. 10/27/10 | Guster | The State Theatre | 8:00pm | | |
| Sat. 10/30/10 | Tiger Saw / St. Claire / Winter Sons / Wesley Allen Hartley & the Traveling Trees | Mayo Street Arts | 8:00pm | | |
| Sun. 10/31/10 | Mayo Street Arts Haunted House and Dance Party | Mayo Street Arts | 8:00pm | | |
| Tue. 11/02/10 | Land Of Talk / Suuns | SPACE Gallery | 8:00pm | | |
| Wed. 11/03/10 | Matt & Kim | Port City Music Hall | 8:00pm | | |
| Fri. 11/05/10 | Brown Bird / The Wrong Reasons / Dana Gross | The Oak & The Ax | 8:00pm | | |
| Sat. 11/06/10 | Michael Franti & Spearhead | The State Theatre | 8:00pm | | |
| Sat. 11/13/10 | Knaughty Sarah's Birthday Party: Covered in Bees / The Handme Downs / The Marvels / Lenny Lashley | Geno's | 9:00pm | | |
| Sat. 11/13/10 | EOTO | Port City Music Hall | 8:00pm | | |
| Sat. 11/13/10 | Jakob Battick & Friends / Herbcraft | The Oak & The Ax | 8:00pm | | |
| Fri. 11/19/10 | Martin Sexton | The State Theatre | 8:00pm | | |
| Sat. 11/20/10 | O'Death / Jacob And The House Of Fire / The Woes | The Oak & The Ax | 8:00pm | | |
| Sun. 11/21/10 | Robert Sarazin Blake / The Powder Kegs | The Oak & The Ax | 8:00pm | | |
